Our results show that degradation of chondroitin sulfate using chondroitinase ABC can render the environment of the damaged CNS more permissive to axon regeneration. This result confirms that ...

RhoA is a key protein in the intracellular signalling cascades that mediate growth cone collapse and contribute to the failure of axonal regeneration in the injured mammalian CNS. However ...

Capitalizing on potent intrinsic transcriptional programs for axon regeneration can provide opportunities for improving peripheral nerve repair and overcoming the permanent loss of function following ...

Myelin is an insulating structure that wraps around axons, allowing the fast and efficient ... show a reduction in the generation of new oligodendrocytes, and myelin regeneration fails.

Animal models as well as human cells have shown that cnicin significantly accelerates axon (nerve fibers) growth. The study ...

increased CNS inflammation, death Trial planned on primary progressive MS (Yale University, New Haven, CT, USA); study placed on hold Flecainide Antiarrhythmic agent Protects axons, reduces ...

Multiple Sclerosis is a debilitating neurodegnerative disease of the central nervous system in which the immune system targets and destroys myelin sheaths surrounding axons. Progressive and permanent ...