How synthetic bacteria can break down the extracellular matrices of solid tumors to make them more susceptible to cancer ...

The interactions between cells in the tumor microenvironment (TME) are critical to tumor initiation ... demonstrating how carefully tailored media support robust, stress-free tumor models for reliable ...

To deepen understanding and hasten the development of treatments, cancer needs to be modelled ... two-dimensional studies and in vivo animal models. In a mini review from 2002, Tyler Jacks and ...

tumor microenvironment, mechanisms of drug sensitivity and resistance, and epigenetic sources of tumorigenic traits. We draw from fundamental mechanisms of cell and tissue development and homeostasis, ...

Animal studies show that this two-step targeting to-, and activation in-, the tumor microenvironment increases ... patient-derived in vivo cancer models, leading to long-term regression and ...

However, because this scarcity happens in cells buried within hard-to-reach tumor regions, it is challenging to observe ...

PDOs replicate the complexity of human tumors, allowing for advanced studies of the tumor microenvironment ... organoids hold potential to replace animal models, providing insights into TME ...

A new drug strategy that regulates the tumor immune microenvironment may ... and recruited powerful immune T cells to tumors in animal models of PDA, converting the environment around a tumor ...

"This is the first study to quantify the effect of radiation therapy on the ECM in the breast microenvironment ... hydrogels to seed tumor cell lines into the animal models.