Single-cell profiling of human prostate cancer and studies in mouse models show that macrophages expressing SPP1 mediate immunotherapeutic resistance through adenosine pathway activation and ...

Synlogic’s immuno-oncology therapeutic strategies center on altering the tumor microenvironment (TME ... probiotics that target kynurenine and adenosine, both known to be associated with ...

Study uses spatial transcriptomics to map intratumoral heterogeneity and microenvironmental dynamics in triple-negative ...

(CRVS) announced new data highlighting the potential of ciforadenant, the Company's adenosine ... tumor associated macrophages are known to contribute to immunosuppression with the tumor ...

the rate-limiting enzyme critical for adenosine-driven immunosuppression in the tumor microenvironment. I-Mab owns worldwide rights to uliledlimab outside of Greater China. Pharmacokinetic ...

The company focuses on an ATP-adenosine pathway, which is a key driver of immunosuppression in the tumor microenvironment to create and optimize differentiated small-molecule immuno-oncology ...