Figure 4: The N-terminal repressor domain of REST is TSA-sensitive. Figure 6: TSA increased the association of acetylated histone H3 and H4 with GluR2 promoter in C6 glioma but not cortical neurons.

Acetylated histones at active enhancers and promoters recruit bromo and extra terminal repeats (BET) protein called BRD4. We recently demonstrated that de novo mutations in BRD4 cause a ...