Two in 1000 patients carry two variants that result in a complete absence of DPD function – in such patients, exposure to 5-FU is often fatal. If a patient develops toxicity to 5-FU or ...

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Kelsey et al. compared the common chemotherapeutic combination of cisplatin and fluorouracil (5-FU) with a paclitaxel-based regimen. Previous studies have shown pathologic complete response rates ...